Tainted Honey
When sugar was available to early humans, they would be wise to eat as much of it as they could. For us, we're better off avoiding the sugar-filled displays that litter every grocery store checkout.
As the story goes with many things - modern day dangers are a result of excess in a world where our biology is still expecting scarcity. Food, substances, experiences, information - every generation gets a brand new challenge as we thunder down the road of innovation.
Maybe wisdom in the new age is developing the unnatural ability to withdrawal from excess. To opt out of some of the games played at our expense. To step back and say, that's enough.